Job Description
Who We Are For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more. And the more people we reach, the more our impact can grow. We transform lives through genetic discovery. Our Culture Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients. BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients’ lives. Description We are searching for a highly motivated and experienced Scientist to join the Cardiovascular Research group at BioMarin. The candidate will be responsible for designing and executing proof of concept studies as well as IND-enabling in vivo studies to drive the cardiovascular portfolio. The role includes small and large animal model development, managing internal and external in vivo pharmacology studies, conduct data acquisition and analysis, and present experimental findings to internal and external meetings. This position offers a unique career opportunity to work in a dynamic matrix-based team environment to drive early-stage drug development in genetic cardiomyopathies. The successful candidate will interact cross-functionally with members of the Research and Early Development organization, as well as external collaborators, to support our discovery programs in genetic cardiomyopathies. The candidate will need to work collaboratively on multiple projects, be resourceful, organized, independent, detail oriented and an excellent communicator. ResponsibilitiesWork and lead studies to gain an understanding of primary and secondary pharmacology mechanisms, biomarkers, translational potential, and safety for discovery- and development-stage programsImplement and apply in vitro and ex vivo technologies to study cardiovascular physiology and pharmacologyDesign, execute, and report/summarize studies with novel approaches and modalities that demonstrate detailed proof of mechanismServe as in vivo study design leadManage the internal and external sourcing of animal studiesOrganize and maintain animal colonies (rodents and USDA species)Perform a variety of in vivo lab work, including but not limiting to dosing (ip, iv, sc, po), PK/PD studies, model development (internal and with CROs), etc. Expertise with large animals and USDA species is a plusPerform data recording and statistical analysis; Document all experimental procedures and data in ELNWrite protocols for IACUC approval and work with IACUC committeesPresent results, conclusions, and implications to various groups Execute/Report studies to support proposed clinical indications Contribute and serve as primary author for pre-clinical, clinical, and regulatory reports/documents RequirementsRequires an advanced degree, such as PhD, with demonstrable expertise in cardiac physiology, pharmacology, biochemistry, or related discipline (relevant industrial experience is critical).Minimum of 2 years related experience in a cardiovascular laboratory setting; may include post-doctoral experience. Hands-on working and directing knowledge of scientific principles and concepts, as well as of both established and state-of-the-art cardiovascular assessment tools. Demonstrable scientist performance and track record in the field with peer-reviewed publications and accomplishments.Excellent verbal and written communication skills, with a demonstrated ability to work independently and effectively in a team and cross-functional setting. PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19. We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
